After Emily died, Wain became sort of obsessed with cats. He inspired and joined "cat societies," people who were lobbying for the adoption of cats as pets. He also seems to have drawn nothing else after that point, just cats.
At some point, Wain began to draw cats in a very different way. Some said that he had gone insane and, indeed, he was admitted to a mental institution and did seem to struggle with depression for most of his life but there's no evidence that he lost touch with reality in any way. He continued to paint what we might consider "normal" cat pictures, while also exploring the psychedelic patterns like those below.
I don't particularly like his work, to be honest; I just find him fascinating. How did he see these psychedelic images? Where did they come from? Certainly nothing in Victorian England inspired them. If I could travel back in time and talk to anyone, he might be someone I'd choose to visit.